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- 规格参数
- 包装参数
General description
Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the Ito channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.
Immunogen
synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel Kv4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).
Application
Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| species reactivity | rat, human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable,western blot (chemiluminescent): 1:200 |
| UniProt accession no. | Q9UK17 |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... KCND3(3752) rat ... Kcnd3(65195) |
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¥ 1724.25
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¥ 26846.31
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