Anti- MLKL antibody produced in rabbit，100UL，SAB5701334-100UL，Sigma

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订货号： 0BL3991

品牌型号： Sigma SAB5701334-100UL

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最小订货量： 1件

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产品介绍 Product Description

General description

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

Immunogen

A synthesized peptide derived from human MLKL.

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody product type	primary antibodies
clone	monoclonal
form	liquid
species reactivity	rat, human, mouse
concentration	1.33 mg/mL
technique(s)	immunohistochemistry: 1:50-1:200,western blot: 1:500-1:2000
UniProt accession no.	Q8NB16
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MLKL(197259)

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