- 商品介绍
- 规格参数
- 包装参数
Application
Useful for Western blot and in kinases assays as a downstream substrate for SRC or MEK1 kinases.
Biochem/physiol Actions
Recombinant full-length human LKB1(STK11) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. LKB1(STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint (1). STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis (2).
Preparation Note
Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
Store in aliquots at -70°C. Avoid freeze/thaw cycles.
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | 70-95% (SDS-PAGE) |
| form | frozen liquid |
| mol wt | ~85 kDa |
| concentration | 0.2 μg/μL |
| accession no. | NM_000455 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... LKB1(6794) |
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¥ 2622.09
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¥ 2019.57
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¥ 1451.54
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¥ 2068.25
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¥ 8135.09
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¥ 3290.05
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¥ 3812.28
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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¥ 3319.60
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