- 商品介绍
- 规格参数
- 包装参数
General description
Anti-C1S (heavy chain, Cleaved-Arg437 Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg437protein.
The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.
Immunogen
The antiserum was produced against synthesized peptide derived from human C1S.
Immunogen Range: 388-437
Biochem/physiol Actions
Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 47 kDa,antigen 76 kDa |
| species reactivity | human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:20000,western blot: 1:500-1:1000 |
| NCBI accession no. | P09871 |
| UniProt accession no. | P09871 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | proteolytically cleaved (Arg437) |
| Gene Information | human ... C1S(716) |
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| 重量(kg) |
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