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General description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Immunogen
A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
| biological source | rabbit |
| Quality Level | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 11-14, 24-55 |
| species reactivity | rat, mouse, human |
| concentration | 0.63 mg/ml |
| technique(s) | immunofluorescence: 1:50-1:100,western blot: 1:500-1:1000 |
| UniProt accession no. | Q00987 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer166) |
| Gene Information | human ... MDM2(4193) |
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¥ 9207.92
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¥ 4039.86
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¥ 5887.85
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¥ 1653.62
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¥ 3335.66
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¥ 1749.15
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¥ 3796.67
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¥ 70526.15
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¥ 39793.68
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