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General description
Spectrin is a multifunctional protein that has lipid-binding sites within CH (calponin-homology) tandem domains, a PH (pleckstrin homology) domain and triple helical segments. It is located on chromosome 1q23.1.
Spectrin is the major cytoskeletal component in erythrocytes. It is composed of two types of polypeptides known as α and β with molecular weights of 240 and 220 kDa, respectively. The α- and β-chains form heterotetramers which are linked end-to-end via oligomeric actin and band 4.1 protein.
Immunogen
spectrin from freshly prepared human erythrocyte ghosts.
Application
Anti-Spectrin antibody has been used in western blotting immunofluorescence and immunostaining.
Biochem/physiol Actions
Spectrins modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β spectrins are essential for the development of nervous system.
The antibody reacts specifically with the α and β chains of human erythrocyte spectrin.
The spectrin-based membrane skeleton is essential to provide mechanical stability and membrane integrity. It is also responsible for protein organization, trafficking and resilience of erythrocytes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | whole antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| contains | 15 mM sodium azide |
| species reactivity | human |
| technique(s) | western blot: 1:400 |
| UniProt accession no. | P02549 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... SPTA1(6708), SPTB(6710), SPTBN1(6711), SPTBN2(6712), SPTBN4(57731), SPTBN5(51332) |
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¥ 2707.32
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¥ 3275.78
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