- 商品介绍
- 规格参数
- 包装参数
General description
CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Immunogen
Recombinant full length human CD120a
Biochem/physiol Actions
The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
Physical form
Phosphate buffered saline (PBS), pH 7.4
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | unconjugated |
| Quality Level | 100 |
| antibody product type | primary antibodies |
| clone | H398, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| concentration | 1 mg/ml |
| technique(s) | immunohistochemistry: suitable,immunoprecipitation (IP): suitable,FUNC: suitable,flow cytometry: suitable |
| isotype | IgG2a |
| UniProt accession no. | P19438 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TNFRSF1A(7132) |
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