Anti-53BP1 Antibody, clone 8Y3Y4, Rabbit Monoclonal，100UL，SAB5702429-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at ′Lys-15′ (H2AK15Ub and histone H4 dimethylated at ′Lys-20′ (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 53BP1 (Q12888).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IHC, IF/ICC

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
material	colorless
clone	8Y3Y4, monoclonal
form	liquid
mol wt	450 kDa
species reactivity	mouse
concentration	0.5 mg/mL
technique(s)	immunofluorescence: 1:50 - 1:200,immunohistochemistry: 1:50 - 1:200,western blot: 1:500 - 1:2000
color	colorless
isotype	IgG
immunogen sequence	MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDT
UniProt accession no.	Q12888
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... TP53BP1(7158)

长度(mm)
宽度(mm)
高度(mm)
重量(kg)