Anti-BCL2 (Ab-56) antibody produced in rabbit，100UG，SAB4300339-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

BCL2 (B-cell lymphoma 2) consists of pro- and antiapoptotic functions. It belongs to BCL2 family of proteins. It is mapped to chromosome 18q21.3 .
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Immunogen

Peptide sequence around aa. 54-58 (G-H-T-P-H), according to the protein BCL2.

Application

Anti-BCL2 (Ab-56) antibody has been used in western blotting .

Biochem/physiol Actions

Overexpression of BCL2 (B-cell lymphoma 2) results in poor clinical predictions in diffuse large B-cell lymphoma (DLBCL). It plays an important role in the growth and progression of cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~26 kDa
species reactivity	human
concentration	1 mg/mL
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100,indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(G-H-T-P-H)
NCBI accession no.	NP_000624.2
UniProt accession no.	P10415
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... BCL2(596)

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