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- 规格参数
- 包装参数
General description
Homeobox protein DLX-2 (UniProt: Q07687; also known as DLX-2, also known as distal-less homeobox 2) is encoded by the DLX2 gene (Gene ID: 1746) in human. DLX2 is part of the DLX family of transcription factors that share homology with the Drosophila distal-less (Dll) gene. DLX-2 is characterized by its homeodomain, a DNA-binding domain consisting of 60 amino acids that facilitate the binding of DLX-2 to specific DNA sequences to regulate gene expression. It may also contain other domains or motifs that influence its interaction with co-factors and other components of the transcriptional machinery. DLX-2 is involved in the regulation of embryonic development, particularly in the formation of the forebrain, facial structures, and limbs. It acts as a transcription factor that can activate or repress the expression of genes, playing a crucial role in morphogenesis and differentiation. The expression of DLX-2 is primarily observed during embryonic development. It is expressed in specific patterns, particularly within the developing forebrain and branchial arches, regions that give rise to facial structures. After development, DLX-2 expression is significantly reduced and is present at low levels in adult tissues. DLX-2 has been associated craniofacial abnormalities, such as cleft palate and other craniosynostosis syndromes, Neurodevelopmental Disorders like autism spectrum disorder (ASD) and intellectual disabilities. There is evidence suggesting that DLX-2 may be involved in tumorigenesis. It has been reported that DLX-2 can promote the proliferation of osteosarcoma cells and may be involved in the progression of other types of cancer.
We are committed to bringing you greener alternative products, which adhere to one or more of the 12 Principles of Green Chemistry. This antibody is preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed, and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb® antibodies represent an entirely new generation of recombinant monoclonal antibodies. Each ZooMAb® antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb® antibodies are reliably available and ready to ship when you need them.
Immunogen
KLH-conjugated linear peptide corresponding to 16 amino acids from the N-terminal half of human DLX2.
Application
Quality Control Testing
Evaluated by Western Blotting in PC-12 cell lysate.
Western Blotting Analysis: A 1:10,000 dilution of this antibody detected DLX2 in PC-12 cell lysate.
Tested Applications
Western Blotting Analysis: A 1:10,000 dilution from a representative lot detected DLX2 in mouse brain lysates and DLX2 recombinant protein.
Immunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected DLX2 in HEK-293 cells.
Affinity Binding Assay: A representative lot of this antibody bound DLX2 peptide with at least ten thousand-fold (10,000X) higher than with non-specific control peptide.
Immunohistochemistry (Paraffin) Analysis: A 1:1,000 dilution from a representative lot detected DLX2 in human prostate tissue sections.
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
Biochem/physiol Actions
Clone 1C4 is a ZooMAb® rabbit recombinant monoclonal antibody that detects DLX2. It targets an epitope within 16 amino acids from the N-terminal half.
Physical form
Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. The PBS/trehalose components in the ZooMAb formulation can have the appearance of a semi-solid (bead like gel) after lyophilization. This is a normal phenomenon. Please follow the recommended reconstitution procedure in the data sheet to dissolve the semi-solid, bead-like, gel-appearing material. The resulting antibody solution is completely stable and functional as proven by full functional testing. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 µL.
Preparation Note
Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 µL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.
Reconstitute lyophilized antibody pellet with 25μL of ultrapure water or Phosphate Buffered Saline (PBS). Please refer to our reconstitution protocol and the specific application guidance on the suggested starting dilutions and sample type.
Legal Information
ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| recombinant | expressed in HEK 293 cells |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 1C4, recombinant monoclonal |
| description | recombinant, expressed in HEK 293 cells |
| product line | ZooMAb® learn more |
| form | lyophilized |
| mol wt | calculated mol wt 34 kDa,observed mol wt ~38 kDa |
| purified by | using Protein A |
| species reactivity | human, mouse |
| species reactivity (predicted by homology) | monkey, canine, rat, feline, porcine, bovine |
| packaging | antibody small pack of 25 |
| greener alternative product characteristics | Waste Prevention Designing Safer Chemicals Design for Energy Efficiency Learn more about the Principles of Green Chemistry. |
| enhanced validation | recombinant expression Learn more about Antibody Enhanced Validation |
| sustainability | Greener Alternative Product |
| technique(s) | affinity binding assay: suitable,immunocytochemistry: suitable,immunohistochemistry: suitable,western blot: suitable |
| isotype | IgGκ |
| epitope sequence | N-terminal half |
| Protein ID accession no. | NP_004396 |
| UniProt accession no. | Q07687 |
| greener alternative category | Aligned |
| shipped in | ambient |
| storage temp. | 2-8°C |
| Gene Information | human ... DLX2(1746) |
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