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Biochem/physiol Actions
The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation. BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Although Brg1 is involved in chromatin remodeling as a complex with other SWI/SNF proteins, purified BRG1 itself is capable of remodeling mono-nucleosomes and nucleosomal arrays in vitro. Mutations of Brg1 have been found in multiple tumor cell lines.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
| biological source | human |
| recombinant | expressed in insect cells |
| assay | ≥80% (SDS-PAGE) |
| form | frozen liquid |
| mol wt | ~185 kDa |
| packaging | pkg of 5 μg |
| storage condition | avoid repeated freeze/thaw cycles |
| concentration | 300 μg/mL |
| color | clear, colorless |
| NCBI accession no. | NM_003072 |
| UniProt accession no. | P51532 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... SMARCA4(6597) |
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