BAG1 (72-end), GST tagged human,50UG,SRP5165-50UG,Sigma

销售价: ¥ 2612.12 / 件
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订货号 0BN0208
品牌型号 Sigma SRP5165-50UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

BAG1 (also known as BCL2-associated athanogene) is a membrane protein rich in glutamic acid residues that binds to BCL2 and blocks apoptosis or programmed cell death. The BAG1-BCL2 complex enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Overexpression of BAG1 in 3T3 fibroblasts prevents apoptosis in the presence of low serum. BAG1 has also been shown to interact with activated glucocorticoid, androgen, estrogen and progesterone receptors. Binding to these receptors by BAG1 is dependent on receptor activation.


Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.


Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles


技术参数 Specifications
recombinantexpressed in E. coli
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
mol wt ~66 kDa
NCBI accession no.NM_004323
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... BAG1(573)
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