Anti-phospho-EGFR (Y1068) antibody, clone 1B8, Rabbit Monoclonal，1004G，SAB6010076-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).

Immunogen

A synthesized peptide derived from human Phospho-EGFR (Y1068)

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preparation Note

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Other Notes

PE-pY-IN

技术参数 Specifications

recombinant	expressed in HEK 293 F cells
Quality Level	100
conjugate	unconjugated
antibody product type	primary antibodies
clone	1B8, recombinant monoclonal
form	liquid
mol wt	150 kDa
purified by	affinity chromatography
species reactivity	human
concentration	0.5mg/ml
technique(s)	ELISA: 2000:10000,flow cytometry: 1:50-1:200,immunofluorescence: 1:50-1:200,immunohistochemistry: 1:50-1:200
isotype	IgG
UniProt accession no.	P00533
shipped in	wet ice
storage temp.	-10 to -25°C
target post-translational modification	phosphorylation (pTyr1068), phosphorylation (pTyr1068)

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