Anti- PTEN antibody produced in rabbit，100UL，SAB5701196-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Immunogen

A synthesized peptide derived from human PTEN

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody product type	primary antibodies
clone	monoclonal
form	liquid
species reactivity	mouse, rat, human
concentration	0.2 mg/mL
technique(s)	immunohistochemistry: 1:50-1:200,western blot: 1:500-1:2000
UniProt accession no.	P60484
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... PTEN(5728)

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