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General description
Opioid peptides are endogenous neuromodulators that play a major role in nociception by interacting with several membrane receptors. Molecular cloning techniques have characterized the nucleotide sequence of several distinct opioid receptors, including the δ-, κ- and μ-opioid receptors.1 The cloned receptors are highly homologous (65%), differing only at the N- and C-termini and at the extracelluar loops that confer binding specificity. All three receptors interact with heterotrimeric G proteins.
δ-Opioid receptors (DOR) are located postsynaptically on pallidostriatal feedback neurons. DORs also modulate nociception presynaptically in the periaqueductal gray where immunolabeling of DOR has been shown to be intracellular and often associated with large dense-core vesicles. Additionally, receptor autoradiographic investigations have localized DORs to the external plexiform layer of the olfactory bulb, the nucleus accumbens, several layers of the cerebral cortex and several nuclei of the amygdala.
References
1. Goldstein, A. Trends Pharmacol. Sci., 8, 456-459 (1987).
Immunogen
Peptide corresponding to the carboxy-terminal of the opioid δ receptor covalently attached onto a carrier protein.
Biochem/physiol Actions
The antiserum is specific for the COOH terminal of the opioid δ receptor.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | whole antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| mol wt | antigen ~55 kDa |
| species reactivity | mouse (predicted), rat |
| technique(s) | immunocytochemistry: 1:800 using PLP fixed rat brain sections,western blot: 1:800 using whole brain homogenate |
| UniProt accession no. | P33533 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Oprd1(18386) rat ... Oprd1(24613) |
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