- 商品介绍
- 规格参数
- 包装参数
General description
Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.
Immunogen
synthetic phosphopeptide derived from the region of mouse cortactin that is phosphorylated on tyrosine 421.
Application
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit is suitable for immunocytochemistry and western blotting at a working dilution of 1:1,000
Biochem/physiol Actions
Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.
Physical form
Solution in Dulbecco′s PBS, pH 7.3, 1mg/mL BSA, 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous glycerol solution |
| mol wt | antigen 80-85 kDa |
| species reactivity | mouse |
| technique(s) | immunocytochemistry: suitable,western blot: 1:1,000 |
| UniProt accession no. | Q60598 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr421) |
| Gene Information | mouse ... Cttn(13043) |
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