Anti-Phospho-CRK-Y221 antibody produced in rabbit,100UL,SAB5700486-100UL,Sigma

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订货号 0BN5985
品牌型号 Sigma SAB5700486-100UL
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.


Immunogen

A synthetic phosphorylated peptide around Y221 of human CRK (NP_058431.2).


Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.


Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.


技术参数 Specifications
biological sourcerabbit
Quality Level100
antibody formaffinity isolated antibody
antibody product typeprimary antibodies
clonepolyclonal
formbuffered aqueous solution
mol wt 22, 33
species reactivitymouse, human, rat
concentration1.42 mg/ml
technique(s)western blot: 1:500-1:2000
UniProt accession no.P46108
shipped inwet ice
storage temp.−20°C
target post-translational modificationphosphorylation (pTyr221)
Gene Informationhuman ... CRK(1398)
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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