Anti-NOTCH4 antibody produced in rabbit,100UG,N5163-100UG,Sigma

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订货号 0BN7415
品牌型号 Sigma N5163-100UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.


Immunogen

synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.


Biochem/physiol Actions

NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.


Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.


Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


技术参数 Specifications
biological sourcerabbit
Quality Level200
conjugateunconjugated
antibody formaffinity isolated antibody
antibody product typeprimary antibodies
clonepolyclonal
formbuffered aqueous solution
mol wtantigen ~230 kDa,antigen ~80 kDa
species reactivitymouse, human, rat
concentration~1 mg/mL
technique(s)immunohistochemistry: 1:100-1:200,western blot: 1:500-1:1,000
UniProt accession no.Q99466
application(s)research pathology
shipped indry ice
storage temp.−20°C
target post-translational modificationunmodified
Gene Informationhuman ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)
长度(mm)
宽度(mm)
高度(mm)
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