- 商品介绍
- 规格参数
- 包装参数
General description
NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.
Immunogen
synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.
Biochem/physiol Actions
NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~230 kDa,antigen ~80 kDa |
| species reactivity | mouse, human, rat |
| concentration | ~1 mg/mL |
| technique(s) | immunohistochemistry: 1:100-1:200,western blot: 1:500-1:1,000 |
| UniProt accession no. | Q99466 |
| application(s) | research pathology |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... NOTCH4(4855) mouse ... Notch4(18132) rat ... Notch4(406162) |
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