- 商品介绍
- 规格参数
- 包装参数
General description
Cortactin is an actin-related protein 2/3 (Arp2/3) complex–activating and filamentous (F)-actin–binding protein. This protein is coded by CTTN gene that maps to human chromosome 11q13.
Immunogen
The antiserum was produced against synthesized peptide derived from mouse Cortactin around the phosphorylation site of Tyr466.
Immunogen Range: 441-490
Application
Anti-phospho-Cortactin (pTyr421) antibody has been used in western blotting and immunoprecipitation.
Biochem/physiol Actions
Cortactin controls Arp2/3-mediated actin polymerization. This protein also modulates aggressive cancer cell traits like tumor growth, cancer cell invasion and motility, and serum and anchorage-independent growth.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 61 kDa |
| species reactivity | human, rat, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:20000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | Q60598 |
| UniProt accession no. | Q14247 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr466) |
| Gene Information | mouse ... Cttn(13043) |
| 长度(mm) | |
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