- 商品介绍
- 规格参数
- 包装参数
General description
The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 4.
Immunogen Range: 160-209
Biochem/physiol Actions
CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 22 kDa |
| species reactivity | rat, mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:5000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | O14493 |
| UniProt accession no. | O14493 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CLDN4(1364) |
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¥ 5167.58
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¥ 2883.61
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¥ 2573.97
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¥ 3335.66
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¥ 3319.60
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¥ 1564.00
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¥ 3852.13
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¥ 5990.26
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