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General description
Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A or PP2A/B55) is a heterotrimeric holoenzyme consisting of a scaffolding subunit (A), a regulatory subunit (B) and a catalytic subunit (C). The B subunit, based on the homology is classified into four families, and each has several isoforms. B55 subunit is ubiquitously expressed among all the families of PP2A. In human chromosome, the gene PPP2R2A is localized on 8p21.2.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Immunogen
peptide Corresponding to the amino terminal sequence from human PP2A-?protein , according to the protein PPP2R2A.
Biochem/physiol Actions
Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A) protein complexes are critical for many cellular processes including cell growth and differentiation, cell motility, DNA damage response, progression of cell cycle and apoptosis. PP2A/B55 dephosphorylates and activates heat shock factor 1 (HSF 1) directly for various cellular processes. Family with sequence similarity 122A (FAM122A) is a endogenous inhibitor of phosphatase activity of PP2A/B55. Overexpression or dysregulation of PP2A has several implications in the developmental stage, embryonic and neonatal death. Polymorphism of PP2A leading to dysregulation is associated with Alzheimer′s disease and various malignancies. Mutations leading to enhanced activity causes asthma, type II diabetes, chronic obstructive lung disorder. Suppression of PPP2R2A expression by micro-RNA892a (mi-R 892a) promotes the growth of colorectal cancer cells. Somatic deletion mutation of PPP2R2A have a potential role in prostate cancer. PPP2R2A functions as a tumour suppressor gene in numerous cancer types. Downregulation of PPP2R2A along with upregulation of cyclin D1 causes aggressiveness in luminal-like breast cancer. PPP2R2A is known to dephosphorylate Tau protein, whose hyperphosphorylation is associated with Alzheimer′s′ disease.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~40 kDa |
| species reactivity | mouse, human, rat |
| concentration | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (S-E-S-Q-V) |
| NCBI accession no. | NP_001171062.1 |
| UniProt accession no. | P63151 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... PPP2R2A(5520) |
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¥ 1596.77
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¥ 2019.57
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¥ 9207.92
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