Anti-TPO-R/CD110/c-Mpl Antibody, clone 5Q9Z6, Rabbit Monoclonal，100UL，SAB5702181-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 536-635 of human TPO-R/CD110/c-Mpl (P40238).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
material	colorless
clone	5Q9Z6, monoclonal
form	liquid
mol wt	80 kDa
species reactivity	rat, human
concentration	0.80 mg/mL
technique(s)	western blot: 1:500 - 1:2000
color	colorless
isotype	IgG
immunogen sequence	HRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
UniProt accession no.	P40238
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MPL(4352)

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