SGC6870，5MG，SML2760-5MG，Sigma

Biochem/physiol Actions

Potent and selective protein arginine methyltransferase PRMT6 inhibitor.
SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC₅₀ = 77 nM by cell-free assays; IC₅₀ = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.