RET (V804L), active, GST tagged human,10UG,SRP5311-10UG,Sigma

销售价: ¥ 3866.08 / 件
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订货号 0BP6384
品牌型号 Sigma SRP5311-10UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

RET or ret proto-oncogene is a member of the cadherin superfamily that encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis.


Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.


Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.


Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany


技术参数 Specifications
recombinantexpressed in baculovirus infected Sf9 cells
product linePRECISIO®
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
specific activity364-546 nmol/min·mg
mol wt ~74 kDa
NCBI accession no.NM_020630
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... RET(5979)
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