MIP-1 alpha (CCL3) from rat，20UG，SRP3248-20UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1a is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Biochem/physiol Actions

Both MIP-1a and MIP-1b are structurally and functionally related CC chemokines. Recombinant rat MIP-1a is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA

技术参数 Specifications

biological source	rat
recombinant	expressed in E. coli
assay	≥98% (HPLC),≥98% (SDS-PAGE)
form	lyophilized
mol wt	7.8 kDa
packaging	pkg of 20 μg
technique(s)	cell culture \| mammalian: suitable
impurities	<0.1 EU/μg endotoxin, tested
color	white to off-white
UniProt accession no.	P50229
shipped in	wet ice
storage temp.	−20°C
Gene Information	rat ... CCL3(25542)

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