Anti-Nematode SUMO (C-term) antibody produced in rabbit，100UG，SAB1300178-100UG，Sigma

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订货号： 0BP7268

品牌型号： Sigma SAB1300178-100UG

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最小订货量： 1件

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产品介绍 Product Description

General description

Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respects to size and ubiquity – to which eukaryotic proteins are subject. Ubiquitin is the most familiar of the protein modifiers and its activation and transfer to target proteins has been studied for over two decades. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, ~12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes. SUMO research enters now an exciting phase with a promise to help understanding how cells orchestrate the complexities of rapidly regulating protein level and activity. This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of nematode SUMO.

Immunogen

SUMO (NP_490842, 43-77)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of nematode SUMO.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	IgG fraction of antiserum
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
species reactivity	human
technique(s)	indirect ELISA: 1:1000
NCBI accession no.	NP_490842
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... smo-1(266820)

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