Anti-Monkeypox virus/MPXV A29L Antibody (SAA0286),1MG,SAB5900405-1MG,Sigma

销售价: ¥ 12701.89 / 件
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订货号 0BP7542
品牌型号 Sigma SAB5900405-1MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Anti-Monkeypox virus/MPXV A29L Antibody, clone SAA0286, is a monoclonal antibody produced in mouse. It is a single, highly specific, cloned antibody that is directed against the A29L protein of the monkeypox virus. It is composed of two heavy chains and two light chains, linked together by disulfide bonds. The heavy chains contain the antigen-binding region, and the light chains contain the constant region. The antigen-binding region is composed of two variable domains, which are responsible for recognizing and binding to the antigen.


Monkeypox virus (MPXV), like smallpox virus, belongs to the genus Orthopoxvirus. Its morphology is consistent with that of orthopoxvirus, with a brick-shaped or oval shape with rounded corners and a size of 200~400nm. Brick-shaped or oval-shaped, covered by a lipoprotein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core containing a large double-stranded DNA gene body. The genome of Mpox virus is a double-stranded DNA, about 197kb long, and the end of the genome contains an identical but opposite terminal inverted repeat sequence. The virus contains 190 open reading frames, 4 of which are located in terminal inverted repeats. The core proteins of monkeypox virus are A29L, A35R, B6R, M1R, H3L.


Application

ELISA,neutralization


Biochem/physiol Actions

Monoclonal Anti-Monkeypox virus/MPXV A29L Antibody, clone SAA0286 binds to the A29L protein of the monkeypox virus, thereby inhibiting its ability to replicate and spread. This prevents the virus from causing infection and disease. The antibody also has the ability to neutralize the virus, which further prevents it from causing infection.


Packaging

100µg per vial / 1 mg per vial


Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.


技术参数 Specifications
biological sourcemouse
Quality Segment100
recombinantexpressed in CHO cells
conjugateunconjugated
antibody formaffinity purified immunoglobulin
cloneSAA0286, recombinant monoclonal
formliquid
mol wt 150 kDa
species reactivitymonkeypox virus
concentration1 mg/mL
technique(s)ELISA: 1:2000-1:4000,neutralization: 0.01-10 μg/mL
color colorless
pH7.4
isotypeIgG2a, kappa
Protein ID accession no.NP_536566.1
UniProt accession no.Q77HM6
shipped inwet ice
storage temp.-65 to -96°C
target post-translational modificationunmodified
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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