Monoclonal Anti-CD3 FITC produced in mouse，100YL4，SAB4702150-100TST，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Immunogen

human thymocytes followed by Sezary T cells

Biochem/physiol Actions

The antibody UCHT1 recognizes an extracellular epitope on CD3 antigen of the TCR/CD3 complex on mature human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex.

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

技术参数 Specifications

conjugate	FITC conjugate
Quality Segment	100
antibody product type	primary antibodies
clone	UCHT1, monoclonal
form	buffered aqueous solution
species reactivity	(Non-human primates), ( Human)
technique(s)	flow cytometry: suitable
isotype	IgG1
UniProt accession no.	P07766
storage temp.	2-8°C
target post-translational modification	unmodified
Gene Information	human ... CD3E(916)

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