- 商品介绍
- 规格参数
- 包装参数
General description
AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis. AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) and via signaling pathways in response to adiponectin, leptin and CAMKKβ.
Physical form
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 238-322 nmol/min·mg |
| mol wt | ~36 kDa (B2), ~40 kDa (G1), ~69 kDa (A2) |
| NCBI accession no. | NM_002733,NM_005399,NM_006252 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... PRKAA2(5563), PRKAB2(5565), PRKAG1(5571) |
| 长度(mm) | |
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