AMPK (α2/β2/γ1), active, His tagged human,5UG,SRP5003-5UG,Sigma

销售价: ¥ 6620.44 / 件
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订货号 0BP8617
品牌型号 Sigma SRP5003-5UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis. AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) and via signaling pathways in response to adiponectin, leptin and CAMKKβ.


Physical form

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.


Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles


Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany


技术参数 Specifications
recombinantexpressed in baculovirus infected Sf9 cells
product linePRECISIO® Kinase
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
specific activity238-322 nmol/min·mg
mol wt ~36 kDa (B2), ~40 kDa (G1), ~69 kDa (A2)
NCBI accession no.NM_002733,NM_005399,NM_006252
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... PRKAA2(5563), PRKAB2(5565), PRKAG1(5571)
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