Anti-E-Cadherin Antibody, clone 2Q9Y7, Rabbit Monoclonal，100UL，SAB5702948-100UL，Sigma

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订货号： 0BP9640

品牌型号： Sigma SAB5702948-100UL

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最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

General description

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 700-800 of human E-Cadherin (NP_004351.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IHC, IF/ICC

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
material	colorless
clone	2Q9Y7, monoclonal
form	liquid
mol wt	135 kDa
species reactivity	human, rat
concentration	1.00 mg/mL
technique(s)	immunofluorescence: 1:50 - 1:200,immunohistochemistry: 1:50 - 1:200,western blot: 1:500 - 1:1000
color	colorless
isotype	IgG
immunogen sequence	PVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPR
UniProt accession no.	P12830
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	mouse ... CDH1(999)

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