- 商品介绍
- 规格参数
- 包装参数
General description
EPHA2 (ephrin receptor A2) belongs to the Eph family of receptor tyrosine kinases. It is a type I transmembrane protein, and its exoplasmic domain consists of a ligand binding domain in its N-terminal, a cysteine-rich domain, and two fibronectin type III repeats. Its cytoplasmic domain contains a juxtamembrane region, a tyrosine kinase domain, a SAM (sterile-α-motif) motif, and a PDZ-binding domain.
Biochem/physiol Actions
EPHA2 binds to the ephrin-A ligand and has diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process can be reversed by ligation of EPHA2.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| Quality Segment | 200 |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 74-102 nmol/min·mg |
| mol wt | ~72 kDa |
| UniProt accession no. | P29317 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... EPHA2(1969) |
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¥ 4039.86
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¥ 6894.69
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¥ 3335.66
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¥ 2307.00
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¥ 1783.21
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¥ 5061.38
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¥ 2452.91
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¥ 2173.94
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¥ 2888.88
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¥ 58184.19
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¥ 3704.60
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¥ 25801.21
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