- 商品介绍
- 规格参数
- 包装参数
General description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Immunogen
A synthesized peptide derived from human Phospho-Histone H2AX (S139)
Physical form
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Other Notes
QA-pS-QEY
| recombinant | expressed in HEK 293 F cells |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody product type | primary antibodies |
| clone | 1F10, recombinant monoclonal |
| form | liquid |
| mol wt | 150 kDa |
| purified by | affinity chromatography |
| species reactivity | human |
| concentration | 0.33mg/ml |
| technique(s) | ELISA: 2000:10000,flow cytometry: 1:50-1:200,immunofluorescence: 1:50-1:200,immunohistochemistry: 1:50-1:200 |
| isotype | IgG |
| UniProt accession no. | P16104 |
| shipped in | wet ice |
| storage temp. | -10 to -25°C |
| target post-translational modification | phosphorylation (pSer139) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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