Anti-CARD19 antibody produced in rabbit，100UL，HPA010921-100UL，Sigma

General description

C9orf89 (chromosome 9 open reading frame 89) is also known as BinCARD (Bcl10-interacting protein with CARD). It belongs to the superfamily of death-domain proteins. This protein has two isoforms which differ in their C-termini, but have the same caspase recruitment domain (CARD) in the N-termini. C9orf89 is expressed ubiquitously.

Immunogen

caspase recruitment domain family, member 19

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

C9orf89 (chromosome 9 open reading frame 89) interacts with Bcl10, through its CARD (caspase recruitment domain) domain. It reduces the amount of phosphorylated Bcl10, and inhibits the activation of NF-κB by Bcl10. The other isoform of C9orf89, called BinCARD-2 resides in mitochondria and is suggested to have a regulatory role in the mitochondrial redox signaling.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Other Notes

Corresponding Antigen APREST72158

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany