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General description
Parkin gene is located on Drosophila melanogaster chromosome 78C2. This gene codes for the enzyme E3 ubiquitin ligase, which localizes in the cytosol.
Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.
Immunogen
PARKIN (NP_730600, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila Parkin.
Application
Anti-Drosophila Parkin (C-term) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Mutation in the parkin gene leads to Parkinson′s disease. The encoded protein is involved in quality control mechanism for the disposal of abnormal mitochondria, thereby maintaining lifespan and controlling locomotion. Parkin along with PTEN-induced putative kinase 1 (PINK1) targets mitochondria for its degradation through autophagy.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | Drosophila |
| technique(s) | indirect ELISA: 1:1000,western blot: 1:100-1:500 |
| NCBI accession no. | NP_730600 |
| UniProt accession no. | Q7KTX7 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | Drosophila melanogaster ... Park(40336) |
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