Anti-EPS8 (C-terminal) antibody produced in goat，100UG，SAB2501392-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The gene EPS8 (epidermal growth factor receptor pathway substrate 8) is mapped to human chromosome 12p12. The protein has a phosphotyrosine-binding (PTB) domain at the N-terminal, an SH3 (src homology 3) domain and an effector domain at the C-terminal.

Immunogen

Peptide with sequence SGVESFDEGSSH, from the C-terminal region of the protein sequence according to NP_004438.3

Biochem/physiol Actions

EPS8 (epidermal growth factor receptor pathway substrate 8) is a substrate for tyrosine kinases, such as epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and ERBB2 (erb-b2 receptor tyrosine kinase 2). In addition, it also interacts with the Src non-receptor tyrosine kinase. The protein is involved in Rac signaling and receptor endocytosis. It also regulates dendritic cell migration, morphogenesis of intestinal cells and microvilli, and stereocilia activity. It is upregulated in pancreatic cancer and oral squamous cell carcinoma. Mutation in EPS8 is associated with autosomal recessive profound deafness.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

技术参数 Specifications

biological source	goat
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
species reactivity	mouse, canine, human, rat
technique(s)	immunohistochemistry: suitable,indirect ELISA: suitable
UniProt accession no.	Q12929
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... EPS8(2059)

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