Anti-GAD67/GAD1 Antibody, clone 4I8S8, Rabbit Monoclonal，100UL，SAB5702921-100UL，Sigma

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订货号： 0BQ5586

品牌型号： Sigma SAB5702921-100UL

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GAD67/GAD1 (Q99259).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

技术参数 Specifications

biological source	rabbit
Quality Segment	100
material	colorless
clone	4I8S8, monoclonal
form	liquid
mol wt	70 kDa
species reactivity	rat, human
concentration	1.10 mg/mL
technique(s)	western blot: 1:500 - 1:2000
color	colorless
isotype	IgG
immunogen sequence	MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFA
UniProt accession no.	Q99259
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... GAD1(2571)

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