Anti-phospho-MAPT (pSer⁴²²) antibody produced in rabbit，100UG，SAB4300215-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Immunogen

Peptide sequence around phosphorylation site of serine 422 (V-D-S(p)-P-Q), according to the protein MAPT.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~48 kDa, ~62 kDa, ~78 kDa
species reactivity	human, rat, mouse
concentration	1 mg/mL
technique(s)	western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(V-D-SP-P-Q)
NCBI accession no.	NP_001116538.1
UniProt accession no.	P10636
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pSer422)
Gene Information	human ... MAPT(4137)

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