MET (M1250T), active, GST tagged human,10UG,SRP5302-10UG,Sigma

销售价: ¥ 3866.08 / 件
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订货号 0BQ6798
品牌型号 Sigma SRP5302-10UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion. MET(M1250T) is one of the mutant forms of MET.


Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.


Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.


Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany


技术参数 Specifications
recombinantexpressed in baculovirus infected Sf9 cells
product linePRECISIO®
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
specific activity148-222 nmol/min·mg
mol wt ~81 kDa
NCBI accession no.NM_000245
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... MET(4233)
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