Progranulin human，10UG，SRP8014-10UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes.

Biochem/physiol Actions

Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

技术参数 Specifications

biological source	human
recombinant	expressed in HEK 293 cells
conjugate	untagged
assay	>95% (SDS-PAGE)
form	lyophilized
mol wt	~65 kDa by SDS-PAGE
packaging	pkg of 10 μg
storage condition	avoid repeated freeze/thaw cycles
impurities	<0.1 EU/μg endotoxin, tested
color	white
UniProt accession no.	P28799
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... GRN(2896)

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