- 商品介绍
- 规格参数
- 包装参数
General description
5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.
Application
5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.
Biochem/physiol Actions
5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.
Physical form
Aqueous solution
| recombinant | expressed in HEK 293 cells |
| form | frozen liquid |
| mol wt | 58.6 kDa |
| UniProt accession no. | P21589 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... NT5E(4907) |
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¥ 3442.25
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¥ 3372.68
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¥ 6330.00
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¥ 8982.64
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¥ 787.34
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¥ 5990.26
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¥ 145427.01
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¥ 75435.65
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¥ 30616.15
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¥ 200318.99
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¥ 205945.25
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