Anti-FAM83G antibody produced in rabbit，100UL，HPA023369-100UL，Sigma

General description

The gene FAM83G (family with sequence similarity 83 member G), also referred to as PAWS1 (protein associated with SMAD1), is found to be conserved across vertebrates and is a member of a family of hypothetical proteins, FAM83A–H. These proteins contain a conserved N-terminal domain called DUF1669, whose function is yet to be determined. This domain contains a putative pseudo-phospholipase D motif.

Immunogen

Protein FAM83G recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

The gene FAM83G (family with sequence similarity 83 member G) encodes a protein that interacts with SMAD1 (similar to mothers against decapentaplegic 1). Independent of SMAD4, the encoded protein forms a complex with SMAD1 and forms a substrate for type I BMP (bone morphogenetic protein) receptor kinases. PAWS1 also forms a substrate for ALK3 (aurora-like kinase ), a type IA BMP receptor, and its phosphorylation is induced by BMPs. Phosphorylated PAWS1 regulates the expression of NEDD9 (neural precursor cell expressed, developmentally down-regulated 9 ) and ASNS (asparagine synthetase), which are SMAD4-independent BMP target genes. It also regulates the expression of several genes independent of BMP stimulation. PAWS1 is involved in the regulation of BMP pathway.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST75957

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany