Monoclonal Anti-c-Myc tag Biotin produced in mouse，，SAB4702005-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells.

Immunogen

Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.

Biochem/physiol Actions

The antibody 9E10 can be used to detect the c-Myc tag.

Physical form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
Store at 2-8°C. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

技术参数 Specifications

conjugate	biotin conjugate
Quality Segment	100
antibody product type	primary antibodies
clone	9E10, monoclonal
form	buffered aqueous solution
species reactivity	( Human), (Tagged fusion proteins in all species)
concentration	1 mg/ml
technique(s)	flow cytometry: suitable,immunohistochemistry: suitable,immunoprecipitation (IP): suitable,western blot: suitable
isotype	IgG1
UniProt accession no.	P01106
storage temp.	2-8°C
target post-translational modification	unmodified
Gene Information	human ... MYC(4609)

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