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- 规格参数
- 包装参数
General description
Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.
Immunogen
GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius
Biochem/physiol Actions
Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.
Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | P2B11, monoclonal |
| form | buffered aqueous glycerol solution |
| mol wt | antigen predicted mol wt 184 kDa |
| species reactivity | human, mouse, bovine, chimpanzee |
| concentration | 1 mg/mL |
| technique(s) | indirect immunofluorescence: suitable,western blot: suitable |
| isotype | IgG1 |
| NCBI accession no. | NP_001010833.2 |
| UniProt accession no. | Q14676 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | mouse ... MDC1(240087) |
| 长度(mm) | |
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| 重量(kg) |
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询价
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¥ 1573.49
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¥ 2019.57
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¥ 2068.25
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¥ 9207.92
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¥ 1568.60
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¥ 1509.00
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¥ 1476.40
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¥ 2911.61
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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¥ 64659.66
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