Anti-SPECC1 antibody produced in rabbit，100UL，HPA021430-100UL，Sigma

General description

The gene SPECC1 (sperm antigen with calponin homology and coiled-coil domains 1) is mapped to human chromosome 17p11.2. It is mainly expressed in testis and localizes in the nucleus. SPECC1 is commonly referred as NSP5 (nuclear structure protein 5).

Immunogen

Sperm antigen with calponin homology and coiled-coil domains 1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

SPECC1 (sperm antigen with calponin homology and coiled-coil domains 1) is up-regulated in certain cancer cells. It mediates apoptosis in head and neck carcinoma. SPECC1 associates with B23 (nucleophosmin) and ribonuclear protein HNRNPL (heterogeneous nuclear ribonucleoprotein L), suggesting its role in ribosome biogenesis and rRNA transcription. Chromosomal translocation in juvenile myelomonocytic leukemia results in SPECC1-PDGFRB (platelet-derived growth factor receptor β) fusion protein.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST75594

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany