- 商品介绍
- 规格参数
- 包装参数
General description
SILu™Prot TIMP1 is a recombinant, stable isotope-labeled human TIMP1 which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of TIMP1 in mass-spectrometry. SILu™Prot TIMP1 is a protein of 184 amino acids , with a calculated molecular mass of 20.7 kDa.
Biochem/physiol Actions
TIMP-1 is glycoprotein that is over-expressed in the supernatant of tissue extracts of breast, gastric, colorectal, and hepatocellular carcinomas. It belongs to the family of “tissue inhibitors of metalloproteinases,” a group of proteins that help regulate bone turnover. TIMP-1 serum levels are significantly associated with HER2 extracellular domain (ECD)-positivity and poorer disease-free survival among primary breast cancer patients with HER2 overexpression. High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with bortezomib and/or IMiDs during their disease course.
Physical form
Supplied as a lyophilized powder containing phosphate buffered saline.
Other Notes
CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
Legal Information
SILu is a trademark of Sigma-Aldrich Co. LLC
| recombinant | expressed in HEK 293 cells |
| Quality Segment | 200 |
| assay | ≥98% (SDS-PAGE) |
| form | lyophilized powder |
| potency | ≥98% Heavy amino acids incorporation efficiency by MS |
| suitability | suitable for mass spectrometry (standard) |
| UniProt accession no. | P01033 |
| storage temp. | −20°C |
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¥ 2814.26
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¥ 3109.49
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¥ 5725.45
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¥ 3812.28
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¥ 5061.38
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¥ 2173.94
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¥ 5990.26
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¥ 15537.49
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¥ 14722.42
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