RO-52 (SSA) human，100UG，R8526-100UG，Sigma

General description

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

Application

RO-52 (SSA) human has been used:

• as a component of the autoantigen array
• to immobilise protein on the self-assembly monolayer
• in enzyme-linked immunosorbent assays (ELISAs)

Biochem/physiol Actions

RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

Physical form

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.