- 商品介绍
- 规格参数
- 包装参数
General description
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
Physical form
Lyophilized from 0.2 μm-filtered solution in PBS.
Preparation Note
Reconstitute at 100 μg/mL in sterile PBS.
Other Notes
The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.
| biological source | human |
| recombinant | expressed in CHO cells |
| assay | ≥98% (SDS-PAGE) |
| form | lyophilized |
| mol wt | monomer 57 kDa by calculation |
| packaging | pkg of 100 μg |
| storage condition | avoid repeated freeze/thaw cycles |
| impurities | <0.06 EU/μg endotoxin, tested |
| color | white |
| UniProt accession no. | Q96D42 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... HAVCR1(26762) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 1573.49
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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