- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Inactive control for PRMT5 degrader MS4322.
MS4370 is an inactive control for PRMT5 degrader MS4322. It comprises of PRMT5 inhibitor EPZ015666 is linked to a von Hippel-Lindau (VHL) E3 ligase ligand (R,S,S)-AHPC-Me (diastereoisomer of VHL-2) that acts as a potent, cell-permeable PRMT5 inhibitor (IC50 = 12 nM). MS4730 does neither degrade PRMT5 nor reduce PRMT5 protein levels at 5 µM, and thus serves as a suitable control for MS4322.
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(C1=NC=NC(NC2CN(C(COCCOCCOCCOCCOCC(N[C@H](C(N3[C@@H](C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C[C@H](O)C3)=O)C(C)(C)C)=O)=O)C2)=C1)NC[C@H](O)CN6CC7=C(C=CC=C7)CC6 |
| InChI | 1S/C55H76N10O12S/c1-36(38-10-12-40(13-11-38)50-37(2)59-35-78-50)60-53(71)46-24-43(66)31-65(46)54(72)51(55(3,4)5)62-48(68)32-76-22-20-74-18-16-73-17-19-75-21-23-77-33-49(69)64-28-42(29-64)61-47-25-45(57-34-58-47)52(70)56-26-44(67)30-63-15-14-39-8-6-7-9-41( |
| InChI key | XUJMNOQMXWVXQE-KPPAQSJOSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1148.92
-
¥ 2528.88
-
¥ 2013.69
-
¥ 2019.57
-
¥ 4039.86
-
询价
-
询价
-
¥ 1724.25
-
¥ 1956.41
-
¥ 9737.84
-
询价
-
询价
-
¥ 2617.87
-
¥ 4011.97
-
¥ 4020.77
-
¥ 3031.24
-
¥ 2452.91
-
¥ 2288.54
-
¥ 70526.15
微信小程序
7X24小时在线咨询