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Biochem/physiol Actions
Orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1); potent Gq-selective agonist of mTAAR1/hTAAR1.
ZH8659 is an orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8659 is a potent Gq-selective agonist of mTAAR1/hTAAR1 (EC50 = 2.6 nM (Gq)). ZH8659 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
Disclaimer
Hygroscopic
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | NCCC1=CC=C(C2=CC=CO2)C=C1.Cl |
| InChI | 1S/C12H13NO.ClH/c13-8-7-10-3-5-11(6-4-10)12-2-1-9-14-12;/h1-6,9H,7-8,13H2;1H |
| InChI key | PIDHDDFXZYDGMH-UHFFFAOYSA-N |
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¥ 1259.40
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¥ 2013.69
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¥ 6894.69
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¥ 4897.21
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¥ 15214.65
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¥ 4404.38
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¥ 2617.87
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¥ 2754.43
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