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Anti-ITGB3 (Ab-773) antibody produced in rabbit，100UG，SAB4300361-100UG，Sigma

销售价： ¥ 4386.94 / 件

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订货号： 0BR5678

品牌型号： Sigma SAB4300361-100UG

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最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

ITGB3 (integrin subunit β3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Immunogen

Peptide sequence around aa. 771-775 (P-L-Y-K-E), according to the protein ITGB3.

Biochem/physiol Actions

Mutations in ITGB3 (integrin subunit β3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells, promoted by reactive oxygen species.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~110 kDa
species reactivity	human, rat, mouse
concentration	1 mg/mL
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100,western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(P-L-Y-K-E)
NCBI accession no.	NP_000203.2
UniProt accession no.	P05106
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... ITGB3(3690)

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